Good Boy!

Molly Shannon

Mrs. Baker

Liam Aiken

Owen Baker

Matthew Broderick

Hubble (voice)

Donald Faison

Wilson (voice)

Cheech Marin

The Greater Dane's Henchman (voice)

Brittany Murphy

Nelly (voice)

Vanessa Redgrave

The Greater Dane (voice)

Carl Reiner

Shep (voice)

Delta Burke

Barbara Ann (voice)

Kevin Nealon

Mr. Baker

Hunter Elliott

Frankie

Mikhael Speidel

Fred

Brittany Moldowan

Connie Fleming

George Touliatos

Mr. Leone

Patti Allan

Ms. Ryan

Ben Immanuel

Wilson's Dad (as Benjamin Ratner)

Peter Flemming

Wilson's Other Dad

Paul Vogt

Bob the Dog Catcher (as Paul C. Vogt)

Brenda Crichlow

Mrs. Fleming (as Brenda M. Crichlow)

D. Harlan Cutshall

Mr. Fleming

Chaka White

Woman at the Pound

Nicola Anderson

Woman at the Pound

Ted Friend

TV Anchorman

Susan Bain

House Bidder